Version 5.4
Homo sapiens Gene: SRSF4
Summary
InnateDB Gene IDBG-95327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF4
Gene Name serine/arginine-rich splicing factor 4
Synonyms SFRS4; SRP75
Species Homo sapiens
Ensembl Gene ENSG00000116350
Encoded Proteins
IDBP-95329
serine/arginine-rich splicing factor 4
IDBP-810282
serine/arginine-rich splicing factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:29147743-29181987
Strand Reverse strand
Band p35.3
Transcripts
ENST00000373795 ENSP00000362900
ENST00000466448
ENST00000497015
ENST00000477193
ENST00000489898
ENST00000472353
ENST00000622143
ENST00000605204 ENSP00000473728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt Q08170
TrEMBL
UniProt Splice Variant
Entrez Gene 6429
UniGene Hs.469970 Hs.634091
RefSeq NM_005626
HUGO HGNC:10786
OMIM 601940
CCDS CCDS333
HPRD 09052
IMGT
EMBL AC004236 AL357500 AL590729 BC002781 BT007415 L14076
GenPept AAA36649 AAC04476 AAH02781 AAP36083 CAH71635 CAI14326
RNA Seq Atlas 6429

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca