Version 5.4
Homo sapiens Protein: SRSF4
Summary
InnateDB Protein IDBP-95329.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF4
Protein Name serine/arginine-rich splicing factor 4
Synonyms SFRS4; SRP75;
Species Homo sapiens
Ensembl Protein ENSP00000362900
InnateDB Gene IDBG-95327 (SRSF4)
Protein Structure
UniProt Annotation
Function Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269PubMed:15009664}.
Subcellular Localization Nucleus speckle {ECO:0000269PubMed:14578391}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08170
PhosphoSite PhosphoSite-Q08170
TrEMBL
UniProt Splice Variant
Entrez Gene 6429
UniGene Hs.634091
RefSeq NP_005617
HUGO HGNC:10786
OMIM 601940
CCDS CCDS333
HPRD 09052
IMGT
EMBL AC004236 AL357500 AL590729 BC002781 BT007415 L14076
GenPept AAA36649 AAC04476 AAH02781 AAP36083 CAH71635 CAI14326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca