Homo sapiens Gene: KPNA6
Summary
InnateDB Gene IDBG-95575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KPNA6
Gene Name karyopherin alpha 6 (importin alpha 7)
Synonyms IPOA7; KPNA7;
Species Homo sapiens
Ensembl Gene ENSG00000025800
Encoded Proteins
karyopherin alpha 6 (importin alpha 7)
karyopherin alpha 6 (importin alpha 7)
karyopherin alpha 6 (importin alpha 7)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32108038-32176568
Strand Forward strand
Band p35.2
Transcripts
ENST00000373625 ENSP00000362728
ENST00000446515 ENSP00000415677
ENST00000471599 ENSP00000474234
ENST00000469790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
Biological Process
GO:0006606 protein import into nucleus
GO:0006607 NLS-bearing protein import into nucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O60684
TrEMBL F5H4G7 G1UI19
UniProt Splice Variant
Entrez Gene 23633
UniGene Hs.470588 Hs.602987 Hs.711019
RefSeq NM_012316 XM_005270711
HUGO HGNC:6399
OMIM 610563
CCDS CCDS352
HPRD 09465
IMGT
EMBL AB621806 AF060543 AK315490 AL049795 AL445248 BC020520 BT009843 CH471059
GenPept AAC15233 AAH20520 AAP88845 BAG37874 BAK64142 CAH71948 CAI22056 EAX07567 EAX07568
RNA Seq Atlas 23633