InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GOPC

Summary

InnateDB Gene

IDBG-95826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOPC

Gene Name

golgi-associated PDZ and coiled-coil motif containing

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000047932

Encoded Proteins

IDBP-95830

golgi-associated PDZ and coiled-coil motif containing

IDBP-95832

golgi-associated PDZ and coiled-coil motif containing

IDBP-603491

golgi-associated PDZ and coiled-coil motif containing

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16878151

GOPC (cystic fibrosis transmembrane regulator-associated ligand) interacts with human papillomavirus type 16 E6 protein to promote E6-associated protein (E6AP)-mediated ubiquitination and proteasomal degradation.

Entrez Gene

Summary

This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:117318211-117602542

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000368498	ENSP00000357484
ENST00000052569	ENSP00000052569
ENST00000467125
ENST00000535237	ENSP00000445690

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 104 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	104 [view]
Protein-Protein	101 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0044325	ion channel binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006893	Golgi to plasma membrane transport
GO:0007289	spermatid nucleus differentiation
GO:0015031	protein transport
GO:0043004	cytoplasmic sequestering of CFTR protein
GO:0045087	innate immune response (InnateDB)
GO:0045176	apical protein localization
GO:0050790	regulation of catalytic activity
GO:0051260	protein homooligomerization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030140	trans-Golgi network transport vesicle
GO:0030425	dendrite
GO:0043234	protein complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019861

View Gene Order

ENSBTAG00000016046

Not yet available

Cross-References

SwissProt

Q9HD26

TrEMBL

T1WEI3 T1WFC1

UniProt Splice Variant

Entrez Gene

57120

UniGene

Hs.191539 Hs.680468 Hs.688290 Hs.690128

RefSeq

NM_001017408 NM_020399

HUGO

HGNC:17643

OMIM

606845

CCDS

CCDS34523 CCDS5117

HPRD

IMGT

EMBL

AB209385 AF287894 AF450008 AL589939 AY033606 BC009553 CH471051 KF420122 KF420123 Z85999

GenPept

AAG00572 AAH09553 AAK57733 AAL47160 AGU13713 AGU13714 BAD92622 CAH70198 CAH70199 CAI43172 CAI43173 EAW48205

RNA Seq Atlas

57120