InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GOPC

Summary

InnateDB Protein

IDBP-95830.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOPC

Protein Name

golgi-associated PDZ and coiled-coil motif containing

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357484

InnateDB Gene

IDBG-95826 (GOPC)

Protein Structure

UniProt Annotation

Function

Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. {ECO:0000269PubMed:11707463, ECO:0000269PubMed:14570915, ECO:0000269PubMed:15358775}.

Subcellular Localization

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. {ECO:0000269PubMed:12661006}.

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:11162552, ECO:0000269PubMed:11384996, ECO:0000269PubMed:11707463}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 104 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	104 [view]
Protein-Protein	101 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0044325	ion channel binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006893	Golgi to plasma membrane transport
GO:0007289	spermatid nucleus differentiation
GO:0015031	protein transport
GO:0043004	cytoplasmic sequestering of CFTR protein
GO:0045087	innate immune response (InnateDB)
GO:0045176	apical protein localization
GO:0050790	regulation of catalytic activity
GO:0051260	protein homooligomerization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030140	trans-Golgi network transport vesicle
GO:0030425	dendrite
GO:0043234	protein complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane