Version 5.4
Homo sapiens Gene: GJA4
Summary
InnateDB Gene IDBG-96023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJA4
Gene Name gap junction protein, alpha 4, 37kDa
Synonyms CX37
Species Homo sapiens
Ensembl Gene ENSG00000187513
Encoded Proteins
IDBP-96025
gap junction protein, alpha 4, 37kDa
IDBP-379439
gap junction protein, alpha 4, 37kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:34792998-34795747
Strand Forward strand
Band p34.3
Transcripts
ENST00000342280 ENSP00000343676
ENST00000450137 ENSP00000409186
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001568 blood vessel development
GO:0003158 endothelium development
GO:0006810 transport
GO:0006816 calcium ion transport
GO:0007043 cell-cell junction assembly
GO:0007267 cell-cell signaling
GO:0048265 response to pain
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050234
View Gene Order
ENSBTAG00000013881
Not yet available
Pathways
NETPATH
REACTOME
REACT_9509
Gap junction assembly pathway
REACT_9411
Gap junction trafficking pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P35212
TrEMBL Q5JW71
UniProt Splice Variant
Entrez Gene 2701
UniGene Hs.296310
RefSeq NM_002060 XM_005270750
HUGO HGNC:4278
OMIM 121012
CCDS CCDS30669
HPRD
IMGT
EMBL AF132674 AF139100 AF139101 AF139102 AF139103 AF139104 AF139105 AF181620 AK291563 AL121988 BC027889 BC072389 CH471059 M96789
GenPept AAA52558 AAD31869 AAD31870 AAD31871 AAD31872 AAD31873 AAD31874 AAD56940 AAF62342 AAH27889 AAH72389 BAF84252 CAB90268 EAX07440 EAX07441
RNA Seq Atlas 2701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca