Homo sapiens Gene: MTF1
Summary
InnateDB Gene IDBG-96513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTF1
Gene Name metal-regulatory transcription factor 1
Synonyms MTF-1; ZRF
Species Homo sapiens
Ensembl Gene ENSG00000188786
Encoded Proteins
metal-regulatory transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:37809567-37859620
Strand Reverse strand
Band p34.3
Transcripts
ENST00000373036 ENSP00000362127
ENST00000468190
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0035035 histone acetyltransferase binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006979 response to oxidative stress
GO:0010038 response to metal ion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046686 response to cadmium ion
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q14872
TrEMBL O14945
UniProt Splice Variant
Entrez Gene 4520
UniGene Hs.471991
RefSeq NM_005955
HUGO HGNC:7428
OMIM 600172
CCDS CCDS30676
HPRD
IMGT
EMBL AK314233 AL929472 BC014454 CH471059 D31907 X78710
GenPept AAH14454 BAA22262 BAG36903 CAA55363 CAH70087 EAX07312
RNA Seq Atlas 4520