InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MTF1

Summary

InnateDB Protein

IDBP-96515.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTF1

Protein Name

metal-regulatory transcription factor 1

Synonyms

MTF-1; ZRF;

Species

Homo sapiens

Ensembl Protein

ENSP00000362127

InnateDB Gene

IDBG-96513 (MTF1)

Protein Structure

UniProt Annotation

Function

Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). {ECO:0000269PubMed:8065932}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006979	response to oxidative stress
GO:0010038	response to metal ion
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046686	response to cadmium ion