Homo sapiens Gene: TCF21
InnateDB Gene IDBG-96735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF21
Gene Name transcription factor 21
Synonyms bHLHa23; POD1;
Species Homo sapiens
Ensembl Gene ENSG00000118526
Encoded Proteins
transcription factor 21
transcription factor 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:133889138-133895553
Strand Forward strand
Band q23.2
ENST00000367882 ENSP00000356857
ENST00000237316 ENSP00000237316
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515 protein binding
GO:0042826 histone deacetylase binding
GO:0043425 bHLH transcription factor binding
GO:0046983 protein dimerization activity
GO:0050681 androgen receptor binding
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001944 vasculature development
GO:0006351 transcription, DNA-templated
GO:0007530 sex determination
GO:0007548 sex differentiation
GO:0009887 organ morphogenesis
GO:0014707 branchiomeric skeletal muscle development
GO:0030855 epithelial cell differentiation
GO:0032835 glomerulus development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048286 lung alveolus development
GO:0048536 spleen development
GO:0048557 embryonic digestive tract morphogenesis
GO:0048608 reproductive structure development
GO:0048732 gland development
GO:0060008 Sertoli cell differentiation
GO:0060021 palate development
GO:0060425 lung morphogenesis
GO:0060426 lung vasculature development
GO:0060435 bronchiole development
GO:0060539 diaphragm development
GO:0060541 respiratory system development
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072277 metanephric glomerular capillary formation
Cellular Component
GO:0005634 nucleus
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
SwissProt O43680
UniProt Splice Variant
Entrez Gene 6943
UniGene Hs.601080 Hs.730198 Hs.78061
RefSeq NM_003206 NM_198392
OMIM 603306
EMBL AF035718 AF047419 AL356109 BC025697 BT019660 CH471051 CR450293
GenPept AAC62514 AAC62532 AAH25697 AAV38466 CAC26822 CAG29289 EAW48000 EAW48001
RNA Seq Atlas 6943