InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TCF21

Summary

InnateDB Gene

IDBG-96735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCF21

Gene Name

transcription factor 21

Synonyms

bHLHa23; POD1

Species

Homo sapiens

Ensembl Gene

ENSG00000118526

Encoded Proteins

IDBP-96737

transcription factor 21

IDBP-96739

transcription factor 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:133889138-133895553

Strand

Forward strand

Band

q23.2

Transcripts

ENST00000367882	ENSP00000356857
ENST00000237316	ENSP00000237316

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0046983	protein dimerization activity
GO:0050681	androgen receptor binding
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001763	morphogenesis of a branching structure
GO:0001822	kidney development
GO:0001944	vasculature development
GO:0006351	transcription, DNA-templated
GO:0007530	sex determination
GO:0007548	sex differentiation
GO:0009887	organ morphogenesis
GO:0014707	branchiomeric skeletal muscle development
GO:0030855	epithelial cell differentiation
GO:0032835	glomerulus development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048286	lung alveolus development
GO:0048536	spleen development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048608	reproductive structure development
GO:0048732	gland development
GO:0060008	Sertoli cell differentiation
GO:0060021	palate development
GO:0060425	lung morphogenesis
GO:0060426	lung vasculature development
GO:0060435	bronchiole development
GO:0060539	diaphragm development
GO:0060541	respiratory system development
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0072162	metanephric mesenchymal cell differentiation
GO:0072277	metanephric glomerular capillary formation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000045680

View Gene Order

ENSBTAG00000021827

Not yet available

Cross-References

SwissProt

O43680

TrEMBL

UniProt Splice Variant

Entrez Gene

6943

UniGene

Hs.601080 Hs.730198 Hs.78061

RefSeq

NM_003206 NM_198392

HUGO

HGNC:11632

OMIM

603306

CCDS

CCDS5167

HPRD

04493

IMGT

EMBL

AF035718 AF047419 AL356109 BC025697 BT019660 CH471051 CR450293

GenPept

AAC62514 AAC62532 AAH25697 AAV38466 CAC26822 CAG29289 EAW48000 EAW48001

RNA Seq Atlas

6943