Version 5.4
Homo sapiens Gene: TBPL1
Summary
InnateDB Gene IDBG-96757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBPL1
Gene Name TBP-like 1
Synonyms MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2
Species Homo sapiens
Ensembl Gene ENSG00000028839
Encoded Proteins
IDBP-96759
TBP-like 1
IDBP-96761
TBP-like 1
IDBP-96763
TBP-like 1
IDBP-387292
TBP-like 1
IDBP-387294
TBP-like 1
IDBP-812038
TBP-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:133952170-133990432
Strand Forward strand
Band q23.2
Transcripts
ENST00000237264 ENSP00000237264
ENST00000367871 ENSP00000356845
ENST00000367869 ENSP00000356843
ENST00000416965 ENSP00000402864
ENST00000457715 ENSP00000398186
ENST00000477527
ENST00000481694
ENST00000613034 ENSP00000478795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0001675 acrosome assembly
GO:0006235 dTTP biosynthetic process
GO:0006352 DNA-templated transcription, initiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0007289 spermatid nucleus differentiation
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005672 transcription factor TFIIA complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071359
View Gene Order
ENSBTAG00000035370
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03022
Basal transcription factors pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001253676 NM_004865
HUGO
OMIM
CCDS CCDS5168
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca