Homo sapiens Gene: TBPL1
Summary
InnateDB Gene IDBG-96757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBPL1
Gene Name TBP-like 1
Synonyms MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2;
Species Homo sapiens
Ensembl Gene ENSG00000028839
Encoded Proteins
TBP-like 1
TBP-like 1
TBP-like 1
TBP-like 1
TBP-like 1
TBP-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:133952170-133990432
Strand Forward strand
Band q23.2
Transcripts
ENST00000237264 ENSP00000237264
ENST00000367871 ENSP00000356845
ENST00000367869 ENSP00000356843
ENST00000416965 ENSP00000402864
ENST00000457715 ENSP00000398186
ENST00000477527
ENST00000481694
ENST00000613034 ENSP00000478795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 23 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0001675 acrosome assembly
GO:0006235 dTTP biosynthetic process
GO:0006352 DNA-templated transcription, initiation
GO:0006366 transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0007289 spermatid nucleus differentiation
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005672 transcription factor TFIIA complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Basal transcription factors pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001253676 NM_004865
HUGO
OMIM
CCDS CCDS5168
HPRD 09272
IMGT
EMBL
GenPept
RNA Seq Atlas