InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBPL1

Summary

InnateDB Protein

IDBP-96759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBPL1

Protein Name

TBP-like 1

Synonyms

MGC:8389; MGC:9620; STUD; TLF; TLP; TRF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000237264

InnateDB Gene

IDBG-96757 (TBPL1)

Protein Structure

UniProt Annotation

Function

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box. {ECO:0000269PubMed:10082669, ECO:0000269PubMed:10220372, ECO:0000269PubMed:15767669, ECO:0000269PubMed:24958592}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in the testis and ovary. {ECO:0000269PubMed:10082669, ECO:0000269PubMed:17570761}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0001675	acrosome assembly
GO:0006235	dTTP biosynthetic process
GO:0006352	DNA-templated transcription, initiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0007283	spermatogenesis
GO:0007289	spermatid nucleus differentiation
GO:2001141	regulation of RNA biosynthetic process