Version 5.4
Homo sapiens Gene: MYB
Summary
InnateDB Gene IDBG-96852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYB
Gene Name v-myb myeloblastosis viral oncogene homolog (avian)
Synonyms c-myb; c-myb_CDS; Cmyb; efg
Species Homo sapiens
Ensembl Gene ENSG00000118513
Encoded Proteins
IDBP-96854
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-96856
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-96858
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-96862
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-96864
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-387385
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-387394
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-387396
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-387397
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-602294
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-583632
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-593556
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-590021
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-584136
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-602669
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-596169
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-597220
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-596823
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-585605
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-587098
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-589849
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-600687
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-599508
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-598114
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-598425
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-584339
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-584283
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-590271
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-584309
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-583415
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-591499
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-588785
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-598441
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-585673
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-584249
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-591166
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-597645
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-594214
v-myb myeloblastosis viral oncogene homolog (avian)
IDBP-808709
v-myb avian myeloblastosis viral oncogene homolog
IDBP-808719
v-myb avian myeloblastosis viral oncogene homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:135181315-135219173
Strand Forward strand
Band q23.3
Transcripts
ENST00000367814 ENSP00000356788
ENST00000367812 ENSP00000356786
ENST00000316528 ENSP00000326328
ENST00000339290 ENSP00000341050
ENST00000341911 ENSP00000339992
ENST00000442647 ENSP00000410825
ENST00000420123 ENSP00000403387
ENST00000430686 ENSP00000390460
ENST00000438901 ENSP00000413011
ENST00000463282 ENSP00000436602
ENST00000525477 ENSP00000437081
ENST00000533837 ENSP00000434639
ENST00000527615 ENSP00000433227
ENST00000525369 ENSP00000435938
ENST00000528140 ENSP00000432877
ENST00000528774 ENSP00000434723
ENST00000534121 ENSP00000432851
ENST00000525940 ENSP00000432948
ENST00000528345 ENSP00000435497
ENST00000534044 ENSP00000435055
ENST00000533624 ENSP00000436605
ENST00000529262 ENSP00000433844
ENST00000528015 ENSP00000434816
ENST00000526187 ENSP00000434795
ENST00000533384 ENSP00000432811
ENST00000531634 ENSP00000436925
ENST00000531737 ENSP00000432168
ENST00000525002 ENSP00000433745
ENST00000524588 ENSP00000434675
ENST00000526565 ENSP00000436385
ENST00000528343 ENSP00000434420
ENST00000525514 ENSP00000435578
ENST00000531519 ENSP00000435595
ENST00000526320 ENSP00000434917
ENST00000526889 ENSP00000433458
ENST00000533808 ENSP00000435293
ENST00000529586 ENSP00000437264
ENST00000531845
ENST00000534736 ENSP00000432042
ENST00000529297
ENST00000618728 ENSP00000479896
ENST00000616088 ENSP00000477898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 87 [view]
Protein-Protein 74 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006816 calcium ion transport
GO:0007596 blood coagulation
GO:0010468 regulation of gene expression
GO:0030183 B cell differentiation
GO:0045624 positive regulation of T-helper cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048538 thymus development
GO:0048566 embryonic digestive tract development
GO:0048872 homeostasis of number of cells
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019982
View Gene Order
ENSBTAG00000012074
Not yet available
Pathways
NETPATH
NetPath_56
Prolactin pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
ap1_pathway
AP-1 transcription factor network
cmyb_pathway
C-MYB transcription factor network
il2_pi3kpathway
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL E9PQQ2 Q708E3 Q9UMI7
UniProt Splice Variant
Entrez Gene 4602
UniGene Hs.606320 Hs.626299 Hs.721437
RefSeq NM_001130172 NM_001130173 NM_001161656 NM_001161657 NM_001161658 NM_001161659 NM_001161660 NM_005375 XM_006715495
HUGO HGNC:7545
OMIM 189990
CCDS CCDS47481 CCDS47482 CCDS5174 CCDS55058 CCDS55059 CCDS55060 CCDS55061 CCDS55062
HPRD 01810
IMGT
EMBL AJ606322 AJ616791 AJ616792 AJ616793 AJ616794 AJ616795 AJ616796 AJ616797 AJ616798 AJ616799 AJ616800 AL023693 CH471051 M95584
GenPept AAA72118 CAE55173 CAF04483 EAW47971
RNA Seq Atlas 4602

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca