InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYB

Summary

InnateDB Protein

IDBP-387396.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYB

Protein Name

v-myb myeloblastosis viral oncogene homolog (avian)

Synonyms

c-myb; c-myb_CDS; Cmyb; efg;

Species

Homo sapiens

Ensembl Protein

ENSP00000390460

InnateDB Gene

IDBG-96852 (MYB)

Protein Structure

UniProt Annotation

Function

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00625, ECO:0000269PubMed:19646965}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	74 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007596	blood coagulation
GO:0045624	positive regulation of T-helper cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051574	positive regulation of histone H3-K9 methylation