Homo sapiens Gene: IFNGR1
Summary
InnateDB Gene IDBG-97020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNGR1
Gene Name interferon gamma receptor 1
Synonyms CD119; IFNGR; IMD27A; IMD27B;
Species Homo sapiens
Ensembl Gene ENSG00000027697
Encoded Proteins
interferon gamma receptor 1
interferon gamma receptor 1
interferon gamma receptor 1
interferon gamma receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IFNGR1, along with IFNGR2, are the receptor subunits for IFN-gamma that upon ligand binding, translocate to the nucleus together with STAT1-alpha, and associate with IFN-gamma-activated sequence (GAS) elements at the promoter sites of IFN-gamma-activated genes.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Expression of Cxcl13, Ifngr1, Retnla and Mrc1 distinguishes between large and small resident peritoneal macrophage subsets.
Entrez Gene
Summary This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:137197484-137219449
Strand Reverse strand
Band q23.3
Transcripts
ENST00000367739 ENSP00000356713
ENST00000458076 ENSP00000389249
ENST00000414770 ENSP00000394230
ENST00000478333
ENST00000543628 ENSP00000443282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 19 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004906 interferon-gamma receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
Biological Process
GO:0007165 signal transduction
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030425 dendrite
GO:0031982 vesicle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
Regulation of IFNG signaling pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Osteoclast differentiation pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
INOH
IFN gamma signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Chaperones modulate interferon signaling pathway [Biocarta view]
Ifn gamma signaling pathway [Biocarta view]
PID NCI
SHP2 signaling
IFN-gamma pathway
Cross-References
SwissProt P15260
TrEMBL A1Z2M9 B4DFT7 E5QBZ2 Q14936 Q5TFC9 Q5TFD1 Q7Z687
UniProt Splice Variant
Entrez Gene 3459
UniGene
RefSeq NM_000416 XM_006715470 XM_006715471
HUGO HGNC:5439
OMIM 107470
CCDS CCDS5185
HPRD
IMGT
EMBL AJ490331 AK294252 AL050337 AY594694 BC005333 BT006814 CH471051 EF173879 HQ670233 HQ670234 HQ670235 HQ670236 HQ670237 J03143 U19241 U19242 U19243 U19244 U19245 U19246 U19247
GenPept AAA52731 AAC52064 AAH05333 AAP35460 AAS89302 ABM53152 ADR72811 ADR72812 ADR72813 ADR72814 ADR72815 BAG57548 CAB53062 CAD35933 EAW47931 EAW47932
RNA Seq Atlas 3459