Homo sapiens Gene: CTPS1
Summary
InnateDB Gene IDBG-97078.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTPS1
Gene Name CTP synthase 1
Synonyms CTPS; IMD24;
Species Homo sapiens
Ensembl Gene ENSG00000171793
Encoded Proteins
CTP synthase
CTP synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq, Jul 2008]
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40979335-41012565
Strand Forward strand
Band p34.2
Transcripts
ENST00000372621 ENSP00000361704
ENST00000372616 ENSP00000361699
ENST00000470271
ENST00000475060
ENST00000479480
ENST00000480420
ENST00000463285
ENST00000486889
ENST00000497210
ENST00000464283
ENST00000463423
ENST00000498694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003883 CTP synthase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0042493 response to drug
GO:0044210 'de novo' CTP biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
INOH
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.473087
RefSeq NM_001301237 NM_001905 XM_005270536 XM_006710390 XM_006710391
HUGO
OMIM
CCDS CCDS459
HPRD 00465
IMGT
EMBL
GenPept
RNA Seq Atlas