Version 5.4
Homo sapiens Gene: FUCA2
Summary
InnateDB Gene IDBG-97335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUCA2
Gene Name fucosidase, alpha-L- 2, plasma
Synonyms dJ20N2.5
Species Homo sapiens
Ensembl Gene ENSG00000001036
Encoded Proteins
IDBP-97337
fucosidase, alpha-L- 2, plasma
IDBP-387605
fucosidase, alpha-L- 2, plasma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20%% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:143494811-143511690
Strand Reverse strand
Band q24.2
Transcripts
ENST00000002165 ENSP00000002165
ENST00000367585
ENST00000451668 ENSP00000398119
ENST00000438118
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004560 alpha-L-fucosidase activity
GO:0042806 fucose binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006004 fucose metabolic process
GO:0009617 response to bacterium
GO:0016139 glycoside catabolic process
GO:2000535 regulation of entry of bacterium into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019810
View Gene Order
ENSBTAG00000001752
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00511
Other glycan degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q7Z6V2
UniProt Splice Variant
Entrez Gene 2519
UniGene Hs.17680 Hs.734934
RefSeq NM_032020
HUGO HGNC:4008
OMIM 136820
CCDS CCDS5200
HPRD 00649
IMGT
EMBL AL031320
GenPept
RNA Seq Atlas 2519

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca