Version 5.4
Homo sapiens Protein: FUCA2
Summary
InnateDB Protein IDBP-97337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUCA2
Protein Name fucosidase, alpha-L- 2, plasma
Synonyms dJ20N2.5;
Species Homo sapiens
Ensembl Protein ENSP00000002165
InnateDB Gene IDBG-97335 (FUCA2)
Protein Structure
UniProt Annotation
Function Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004560 alpha-L-fucosidase activity
GO:0042806 fucose binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006004 fucose metabolic process
GO:0009617 response to bacterium
GO:0016139 glycoside catabolic process
GO:2000535 regulation of entry of bacterium into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000933 Glycoside hydrolase, family 29
IPR016286 Alpha-L-fucosidase, metazoa-type
IPR017853 Glycoside hydrolase, superfamily
PFAM PF01120
PRINTS PR00741
PIRSF PIRSF001092
SMART SM00812
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BTY2
PhosphoSite PhosphoSite-Q9BTY2
TrEMBL
UniProt Splice Variant
Entrez Gene 2519
UniGene Hs.734934
RefSeq NP_114409
HUGO HGNC:4008
OMIM 136820
CCDS CCDS5200
HPRD 00649
IMGT
EMBL AK075458 AL031320 AY358551 BC003060 BC051268
GenPept AAH03060 AAH51268 AAQ88915 BAC11633 CAB53746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca