Version 5.4
Homo sapiens Gene: STX11
Summary
InnateDB Gene IDBG-97425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX11
Gene Name syntaxin 11
Synonyms FHL4; HLH4; HPLH4
Species Homo sapiens
Ensembl Gene ENSG00000135604
Encoded Proteins
IDBP-97427
syntaxin 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:144150526-144188370
Strand Forward strand
Band q24.2
Transcripts
ENST00000367568 ENSP00000356540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
Biological Process
GO:0001913 T cell mediated cytotoxicity
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043312 neutrophil degranulation
GO:0043316 cytotoxic T cell degranulation
GO:0043320 natural killer cell degranulation
GO:0061025 membrane fusion
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039232
View Gene Order
ENSBTAG00000011236
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt O75558
TrEMBL
UniProt Splice Variant
Entrez Gene 8676
UniGene Hs.118958
RefSeq NM_003764 XM_005267189 XM_006715588
HUGO HGNC:11429
OMIM 605014
CCDS CCDS5205
HPRD
IMGT
EMBL AF038898 AF044309 AF071504 AL135917 BC033519 CH471051
GenPept AAC24004 AAC24031 AAD02107 AAH33519 CAI22980 EAW47849 EAW47850
RNA Seq Atlas 8676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca