Version 5.4
Homo sapiens Gene: DMAP1
Summary
InnateDB Gene IDBG-97673.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMAP1
Gene Name DNA methyltransferase 1 associated protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178028
Encoded Proteins
IDBP-97675
DNA methyltransferase 1 associated protein 1
IDBP-97677
DNA methyltransferase 1 associated protein 1
IDBP-97681
DNA methyltransferase 1 associated protein 1
IDBP-97683
DNA methyltransferase 1 associated protein 1
IDBP-382626
DNA methyltransferase 1 associated protein 1
IDBP-382628
DNA methyltransferase 1 associated protein 1
IDBP-382629
DNA methyltransferase 1 associated protein 1
IDBP-382630
DNA methyltransferase 1 associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:44213455-44220681
Strand Forward strand
Band p34.1
Transcripts
ENST00000372290 ENSP00000361364
ENST00000372289 ENSP00000361363
ENST00000361745 ENSP00000354697
ENST00000315913 ENSP00000312697
ENST00000446292 ENSP00000409200
ENST00000440641 ENSP00000401099
ENST00000437511 ENSP00000402494
ENST00000436069 ENSP00000400269
ENST00000475794
ENST00000471829
ENST00000487922
ENST00000463950
ENST00000488433
ENST00000483741
ENST00000494092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 74 [view]
Protein-Protein 69 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006281 DNA repair
GO:0006306 DNA methylation
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0040008 regulation of growth
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0035267 NuA4 histone acetyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009640
View Gene Order
ENSBTAG00000005912
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.662168 Hs.8008
RefSeq NM_001034023 NM_001034024 NM_019100 XM_005271037 XM_005271040
HUGO
OMIM
CCDS CCDS509
HPRD 05465
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca