InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DMAP1

Summary

InnateDB Protein

IDBP-97677.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMAP1

Protein Name

DNA methyltransferase 1 associated protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361363

InnateDB Gene

IDBG-97673 (DMAP1)

Protein Structure

UniProt Annotation

Function

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269PubMed:14665632, ECO:0000269PubMed:14966270, ECO:0000269PubMed:14978102, ECO:0000269PubMed:15367675}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	69 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006306	DNA methylation
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0040008	regulation of growth
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045892	negative regulation of transcription, DNA-templated