Version 5.4
Homo sapiens Gene: RAD54L
Summary
InnateDB Gene IDBG-98098.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD54L
Gene Name RAD54-like (S. cerevisiae)
Synonyms hHR54; HR54; hRAD54; RAD54A
Species Homo sapiens
Ensembl Gene ENSG00000085999
Encoded Proteins
IDBP-98100
RAD54-like (S. cerevisiae)
IDBP-383453
RAD54-like (S. cerevisiae)
IDBP-810004
RAD54-like (S. cerevisiae)
IDBP-810007
RAD54-like (S. cerevisiae)
IDBP-810032
RAD54-like (S. cerevisiae)
IDBP-810033
RAD54-like (S. cerevisiae)
IDBP-810036
RAD54-like (S. cerevisiae)
IDBP-810039
RAD54-like (S. cerevisiae)
IDBP-810043
RAD54-like (S. cerevisiae)
IDBP-810044
RAD54-like (S. cerevisiae)
IDBP-810046
RAD54-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:46247688-46278473
Strand Forward strand
Band p34.1
Transcripts
ENST00000371975 ENSP00000361043
ENST00000442598 ENSP00000396113
ENST00000463715 ENSP00000480207
ENST00000493985 ENSP00000479823
ENST00000469835 ENSP00000477172
ENST00000487700
ENST00000493032 ENSP00000479995
ENST00000472889 ENSP00000477729
ENST00000473251 ENSP00000483843
ENST00000476687 ENSP00000479734
ENST00000488942 ENSP00000476642
ENST00000459678 ENSP00000479155
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 6 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0036310 annealing helicase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000733 DNA strand renaturation
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007126 meiotic nuclear division
GO:0008152 metabolic process
GO:0010212 response to ionizing radiation
GO:0042493 response to drug
GO:0051276 chromosome organization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028702
View Gene Order
ENSBTAG00000019901
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.642042
RefSeq NM_001142548 NM_003579 XM_006710975
HUGO
OMIM
CCDS CCDS532
HPRD 04683
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca