Homo sapiens Gene: CYP4A11
Summary
InnateDB Gene IDBG-98208.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4A11
Gene Name cytochrome P450, family 4, subfamily A, polypeptide 11
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187048
Encoded Proteins
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, family 4, subfamily A, polypeptide 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:46929177-46941484
Strand Reverse strand
Band p33
Transcripts
ENST00000310638 ENSP00000311095
ENST00000371905 ENSP00000360972
ENST00000371904 ENSP00000360971
ENST00000475477 ENSP00000476854
ENST00000462347 ENSP00000477495
ENST00000474458 ENSP00000476988
ENST00000468629 ENSP00000476619
ENST00000465874 ENSP00000476368
ENST00000496519
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008392 arachidonic acid epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685 alkane 1-monooxygenase activity
GO:0020037 heme binding
GO:0050051 leukotriene-B4 20-monooxygenase activity
GO:0052869 arachidonic acid omega-hydroxylase activity
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0003091 renal water homeostasis
GO:0003095 pressure natriuresis
GO:0006631 fatty acid metabolic process
GO:0006691 leukotriene metabolic process
GO:0006805 xenobiotic metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0032305 positive regulation of icosanoid secretion
GO:0036101 leukotriene B4 catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055078 sodium ion homeostasis
GO:0055114 oxidation-reduction process
GO:0097267 omega-hydroxylase P450 pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016324 apical plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway
PPARA activates gene expression pathway
Cytochrome P450 - arranged by substrate type pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Fatty acids pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Biological oxidations pathway
Eicosanoids pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Miscellaneous substrates pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Fatty acid degradation pathway
Arachidonic acid metabolism pathway
Retinol metabolism pathway
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1645
RefSeq NM_000778 XM_005270539 XM_006710392
HUGO
OMIM
CCDS CCDS543
HPRD 03201
IMGT
EMBL
GenPept
RNA Seq Atlas