InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FAF1

Summary

InnateDB Gene

IDBG-98407.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAF1

Gene Name

Fas (TNFRSF6) associated factor 1

Synonyms

hFAF1; HFAF1s; UBXD12; UBXN3A

Species

Homo sapiens

Ensembl Gene

ENSG00000185104

Encoded Proteins

IDBP-98415

Fas (TNFRSF6) associated factor 1

IDBP-238074

Fas (TNFRSF6) associated factor 1

IDBP-587019

Fas (TNFRSF6) associated factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:50439478-50960263

Strand

Reverse strand

Band

p32.3

Transcripts

ENST00000371778	ENSP00000360843
ENST00000396153	ENSP00000379457
ENST00000494400	ENSP00000434929
ENST00000472808
ENST00000487898

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	134 [view]
Protein-Protein	134 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019887	protein kinase regulator activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0006915	apoptotic process
GO:0007253	cytoplasmic sequestering of NF-kappaB
GO:0008219	cell death
GO:0030155	regulation of cell adhesion
GO:0031334	positive regulation of protein complex assembly
GO:0042176	regulation of protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045859	regulation of protein kinase activity
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031265	CD95 death-inducing signaling complex
GO:0034098	Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000010517

View Gene Order

ENSBTAG00000014482

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.530402 Hs.593559 Hs.735217

RefSeq

NM_007051

HUGO

OMIM

CCDS

CCDS554

HPRD

05124

IMGT

EMBL

GenPept

RNA Seq Atlas