Homo sapiens Gene: FAF1
Summary
InnateDB Gene IDBG-98407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAF1
Gene Name Fas (TNFRSF6) associated factor 1
Synonyms hFAF1; HFAF1s; UBXD12; UBXN3A;
Species Homo sapiens
Ensembl Gene ENSG00000185104
Encoded Proteins
Fas (TNFRSF6) associated factor 1
Fas (TNFRSF6) associated factor 1
Fas (TNFRSF6) associated factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:50439478-50960263
Strand Reverse strand
Band p32.3
Transcripts
ENST00000371778 ENSP00000360843
ENST00000396153 ENSP00000379457
ENST00000494400 ENSP00000434929
ENST00000472808
ENST00000487898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 134 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 134 [view]
Protein-Protein 134 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031072 heat shock protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0043130 ubiquitin binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0006915 apoptotic process
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0008219 cell death
GO:0030155 regulation of cell adhesion
GO:0031334 positive regulation of protein complex assembly
GO:0042176 regulation of protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045859 regulation of protein kinase activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031265 CD95 death-inducing signaling complex
GO:0034098 Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Fas signaling pathway (cd95) [Biocarta view]
PID NCI
Cross-References
SwissProt Q9UNN5
TrEMBL B1ANM7
UniProt Splice Variant
Entrez Gene 11124
UniGene Hs.530402 Hs.593559 Hs.735217
RefSeq NM_007051
HUGO HGNC:3578
OMIM 604460
CCDS CCDS554
HPRD 05124
IMGT
EMBL AC091610 AC118557 AF094700 AF106798 AF132938 AF136173 AJ271408 AL049637 AL133631 AL359977 AL603746 BC004970 BC067100 CH471059
GenPept AAD27713 AAD51876 AAD51886 AAH04970 AAH67100 AAP97263 CAB63755 CAB67705 CAH70189 CAH72113 EAX06837
RNA Seq Atlas 11124