Version 5.4
Homo sapiens Gene: ACAT2
Summary
InnateDB Gene IDBG-98567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAT2
Gene Name acetyl-CoA acetyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120437
Encoded Proteins
IDBP-98569
acetyl-CoA acetyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159760328-159779055
Strand Forward strand
Band q25.3
Transcripts
ENST00000367048 ENSP00000356015
ENST00000467951
ENST00000472052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023832
View Gene Order
ENSBTAG00000002827
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00072
Synthesis and degradation of ketone bodies pathway
hsa00071
Fatty acid degradation pathway
hsa00310
Lysine degradation pathway
hsa04975
Fat digestion and absorption pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Butanoate metabolism pathway
INOH website
Citrate cycle pathway
INOH website
Pyruvate metabolism pathway
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt Q9BWD1
TrEMBL
UniProt Splice Variant
Entrez Gene 39
UniGene Hs.571037
RefSeq NM_005891
HUGO HGNC:94
OMIM 100678
CCDS CCDS5268
HPRD
IMGT
EMBL AF356877 AL135914 BC000408 CH471051 S70154
GenPept AAB30856 AAH00408 AAM00223 CAI21850 EAW47619 EAW47620
RNA Seq Atlas 39

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca