Homo sapiens Gene: ACAT2
Summary
InnateDB Gene IDBG-98567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAT2
Gene Name acetyl-CoA acetyltransferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120437
Encoded Proteins
acetyl-CoA acetyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159760328-159779055
Strand Forward strand
Band q25.3
Transcripts
ENST00000367048 ENSP00000356015
ENST00000467951
ENST00000472052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Fatty acid degradation pathway
Synthesis and degradation of ketone bodies pathway
Valine, leucine and isoleucine degradation pathway
Lysine degradation pathway
Tryptophan metabolism pathway
Pyruvate metabolism pathway
Glyoxylate and dicarboxylate metabolism pathway
Propanoate metabolism pathway
Butanoate metabolism pathway
Terpenoid backbone biosynthesis pathway
Fat digestion and absorption pathway
INOH
Lysine degradation pathway
Tryptophan degradation pathway
Butanoate metabolism pathway
Citrate cycle pathway
Pyruvate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9BWD1
TrEMBL
UniProt Splice Variant
Entrez Gene 39
UniGene Hs.571037
RefSeq NM_005891
HUGO HGNC:94
OMIM 100678
CCDS CCDS5268
HPRD 00006
IMGT
EMBL AF356877 AL135914 BC000408 CH471051 S70154
GenPept AAB30856 AAH00408 AAM00223 CAI21850 EAW47619 EAW47620
RNA Seq Atlas 39