Version 5.4
Homo sapiens Gene: MRPL18
Summary
InnateDB Gene IDBG-98576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL18
Gene Name mitochondrial ribosomal protein L18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112110
Encoded Proteins
IDBP-98578
mitochondrial ribosomal protein L18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this gene, one of which is three nt in length which causes an extra aa near the N-terminus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159789812-159798436
Strand Forward strand
Band q25.3
Transcripts
ENST00000367034 ENSP00000356001
ENST00000476826
ENST00000479638
ENST00000480842
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
Biological Process
GO:0006412 translation
GO:0035928 rRNA import into mitochondrion
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000057388
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000001289
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267680
Mitochondrial translation initiation pathway
REACT_267602
Mitochondrial translation termination pathway
REACT_267677
Mitochondrial translation elongation pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.624865 Hs.733151
RefSeq NM_014161
HUGO
OMIM
CCDS CCDS5270
HPRD 14744
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca