Version 5.4
Homo sapiens Protein: MRPL18
Summary
InnateDB Protein IDBP-98578.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL18
Protein Name mitochondrial ribosomal protein L18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356001
InnateDB Gene IDBG-98576 (MRPL18)
Protein Structure
UniProt Annotation
Function Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA. {ECO:0000269PubMed:21685364}.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0008097 5S rRNA binding
Biological Process
GO:0006412 translation
GO:0035928 rRNA import into mitochondrion
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005840 ribosome
Protein Structure and Domains
PDB ID
InterPro IPR005484 Ribosomal protein L18/L5
PFAM PF00861
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H0U6
PhosphoSite PhosphoSite-Q9H0U6
TrEMBL
UniProt Splice Variant
Entrez Gene 29074
UniGene Hs.733151
RefSeq NP_054880
HUGO HGNC:14477
OMIM 611831
CCDS CCDS5270
HPRD 14744
IMGT
EMBL AF161556 AL135914 AL136633 AL139045 BC001623 CR533491
GenPept AAF29043 AAH01623 CAB66568 CAG38522 CAI19751 CAI21852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca