Homo sapiens Gene: TXNDC12
Summary
InnateDB Gene IDBG-98579.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXNDC12
Gene Name thioredoxin domain containing 12 (endoplasmic reticulum)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000117862
Encoded Proteins
thioredoxin domain containing 12 (endoplasmic reticulum)
thioredoxin domain containing 12 (endoplasmic reticulum)
thioredoxin domain containing 12 (endoplasmic reticulum)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:52020131-52056171
Strand Reverse strand
Band p32.3
Transcripts
ENST00000371626 ENSP00000360688
ENST00000469458
ENST00000472624 ENSP00000477120
ENST00000471493
ENST00000610127 ENSP00000476401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019153 protein-disulfide reductase (glutathione) activity
Biological Process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glutathione metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL V9GYV4
UniProt Splice Variant
Entrez Gene 51060
UniGene
RefSeq NM_015913
HUGO HGNC:24626
OMIM 609448
CCDS CCDS561
HPRD
IMGT
EMBL AL445685
GenPept
RNA Seq Atlas 51060