InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAS1

Summary

InnateDB Gene

IDBG-98585.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAS1

Gene Name

MAS1 oncogene

Synonyms

MAS; MGRA

Species

Homo sapiens

Ensembl Gene

ENSG00000130368

Encoded Proteins

IDBP-98587

MAS1 oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:159906690-159916530

Strand

Forward strand

Band

q25.3

Transcripts

ENST00000252660

ENSP00000252660

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001595	angiotensin receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0017046	peptide hormone binding
GO:0042277	peptide binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009653	anatomical structure morphogenesis
GO:0014823	response to activity
GO:0021766	hippocampus development
GO:0034698	response to gonadotropin
GO:0038166	angiotensin-activated signaling pathway
GO:0042493	response to drug
GO:0043434	response to peptide hormone
GO:0045740	positive regulation of DNA replication
GO:0050727	regulation of inflammatory response
GO:0060732	positive regulation of inositol phosphate biosynthetic process
GO:0070528	protein kinase C signaling
GO:0071375	cellular response to peptide hormone stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000068037

View Gene Order

ENSBTAG00000031724

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04614

Renin-angiotensin system pathway

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P04201

TrEMBL

W8W3P4

UniProt Splice Variant

Entrez Gene

4142

UniGene

Hs.99900

RefSeq

NM_002377

HUGO

HGNC:6899

OMIM

165180

CCDS

CCDS5272

HPRD

IMGT

EMBL

AL035691 BC069142 BC069581 BC110454 CH471051 CR542261 HG426065 M13150

GenPept

AAA36199 AAH69142 AAH69581 AAI10455 CAB72444 CAG47057 CDG86183 EAW47610 EAW47611

RNA Seq Atlas

4142