Homo sapiens Gene: IGF2R
Summary
InnateDB Gene IDBG-98588.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF2R
Gene Name insulin-like growth factor 2 receptor
Synonyms CD222; CIMPR; M6P-R; MPR1; MPRI;
Species Homo sapiens
Ensembl Gene ENSG00000197081
Encoded Proteins
insulin-like growth factor 2 receptor
insulin-like growth factor 2 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Oct 2010]
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159969099-160113507
Strand Forward strand
Band q25.3
Transcripts
ENST00000356956 ENSP00000349437
ENST00000464636
ENST00000487607
ENST00000475834 ENSP00000473880
ENST00000475584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0001965 G-protein alpha-subunit binding
GO:0001972 retinoic acid binding
GO:0004872 receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0005537 mannose binding
GO:0019899 enzyme binding
GO:0031995 insulin-like growth factor II binding
GO:0042802 identical protein binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001889 liver development
GO:0006810 transport
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007283 spermatogenesis
GO:0009791 post-embryonic development
GO:0031100 organ regeneration
GO:0032526 response to retinoic acid
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005770 late endosome
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030118 clathrin coat
GO:0030139 endocytic vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 3482
UniGene
RefSeq NM_000876
HUGO HGNC:5467
OMIM 147280
CCDS CCDS5273
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 3482