InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.4977

Summary

InnateDB Gene

IDBG-635488.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.4977

Gene Name

cation-independent mannose-6-phosphate receptor

Synonyms

CI-MPR; CIMPR

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002402

Encoded Proteins

IDBP-687356

cation-independent mannose-6-phosphate receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197081:
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Oct 2010]
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:97638172-97740003

Strand

Forward strand

Band

Transcripts

ENSBTAT00000037678

ENSBTAP00000037502

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0005537	mannose binding
GO:0042802	identical protein binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0006810

transport

Cellular Component

GO:0005634	nucleus
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030139	endocytic vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0070062	extracellular vesicular exosome