Homo sapiens Gene: EIF2S1
Summary
InnateDB Gene IDBG-9859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2S1
Gene Name eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Synonyms EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A;
Species Homo sapiens
Ensembl Gene ENSG00000134001
Encoded Proteins
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67359997-67386516
Strand Forward strand
Band q23.3
Transcripts
ENST00000256383 ENSP00000256383
ENST00000466499 ENSP00000425299
ENST00000556724
ENST00000557310 ENSP00000451975
ENST00000555876 ENSP00000452034
ENST00000554332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 63 [view]
Protein-Protein 59 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0010467 gene expression
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043558 regulation of translational initiation in response to stress
GO:0044267 cellular protein metabolic process
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005844 polysome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL1 pathway
REACTOME
Eukaryotic Translation Initiation pathway
Unfolded Protein Response (UPR) pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
PERK regulates gene expression pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Recycling of eIF2:GDP pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
KEGG
RNA transport pathway
Protein processing in endoplasmic reticulum pathway
Hepatitis C pathway
INOH
PID BIOCARTA
Double stranded rna induced gene expression [Biocarta view]
Regulation of eif2 [Biocarta view]
Eukaryotic protein translation [Biocarta view]
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
PID NCI
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.151777 Hs.597347 Hs.599838
RefSeq NM_004094
HUGO
OMIM
CCDS CCDS9781
HPRD 04881
IMGT
EMBL
GenPept
RNA Seq Atlas