Version 5.4
Homo sapiens Gene: CPT2
Summary
InnateDB Gene IDBG-98702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPT2
Gene Name carnitine palmitoyltransferase 2
Synonyms CPT1; CPTASE; IIAE4
Species Homo sapiens
Ensembl Gene ENSG00000157184
Encoded Proteins
IDBP-98704
carnitine palmitoyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:53196429-53214197
Strand Forward strand
Band p32.3
Transcripts
ENST00000371486 ENSP00000360541
ENST00000468572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004095 carnitine O-palmitoyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006635 fatty acid beta-oxidation
GO:0006853 carnitine shuttle
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028607
View Gene Order
ENSBTAG00000014649
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00071
Fatty acid degradation pathway
hsa03320
PPAR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P23786
TrEMBL
UniProt Splice Variant
Entrez Gene 1376
UniGene Hs.625312 Hs.713535
RefSeq NM_000098
HUGO HGNC:2330
OMIM 600650
CCDS CCDS575
HPRD 02802
IMGT
EMBL AK312687 AL606760 BC002445 BC005172 CH471059 M58581 U09642 U09643 U09644 U09645 U09646 U09648
GenPept AAB59462 AAB60382 AAB60383 AAH02445 AAH05172 BAG35567 CAI18907 EAX06753
RNA Seq Atlas 1376

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca