Homo sapiens Gene: SLC22A3
Summary
InnateDB Gene IDBG-98707.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A3
Gene Name solute carrier family 22 (extraneuronal monoamine transporter), member 3
Synonyms EMT; EMTH; OCT3;
Species Homo sapiens
Ensembl Gene ENSG00000146477
Encoded Proteins
solute carrier family 22 (extraneuronal monoamine transporter), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
SLC22A3 deficiency significantly decreases lipopolysaccharide- induced monocytic inflammatory response by interrupting NF-kB and MAPKs (mitogen-activated protein kinases) signalling cascades in a histamine dependent manner.
Entrez Gene
Summary Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:160348268-160452581
Strand Forward strand
Band q25.3
Transcripts
ENST00000275300 ENSP00000275300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005329 dopamine transmembrane transporter activity
GO:0005515 protein binding
GO:0015075 ion transmembrane transporter activity
GO:0015101 organic cation transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
GO:0019534 toxin transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006855 drug transmembrane transport
GO:0015695 organic cation transport
GO:0015697 quaternary ammonium group transport
GO:0015844 monoamine transport
GO:0015872 dopamine transport
GO:0032098 regulation of appetite
GO:0034220 ion transmembrane transport
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051608 histamine transport
GO:0051615 histamine uptake
GO:0055085 transmembrane transport
GO:1901998 toxin transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Organic cation transport pathway
Abacavir transmembrane transport pathway
Organic cation/anion/zwitterion transport pathway
Abacavir transport and metabolism pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O75751
TrEMBL Q96KH7 Q9NQC0
UniProt Splice Variant
Entrez Gene 6581
UniGene Hs.606278 Hs.742534
RefSeq NM_021977 XM_005267106
HUGO HGNC:10967
OMIM 604842
CCDS CCDS5277
HPRD
IMGT
EMBL AF078749 AJ001417 AJ251884 AJ403946 AJ403947 AJ403948 AJ403949 AJ403950 AJ403951 AJ403952 AJ403953 AK314590 AL355506 AL591069 CH471051
GenPept AAD20977 BAG37164 CAA04751 CAB96132 CAC39443 CAI16539 CAI20340 EAW47599
RNA Seq Atlas 6581