InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC22A3

Summary

InnateDB Protein

IDBP-98709.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC22A3

Protein Name

solute carrier family 22 (extraneuronal monoamine transporter), member 3

Synonyms

EMT; EMTH; OCT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000275300

InnateDB Gene

IDBG-98707 (SLC22A3)

Protein Structure

UniProt Annotation

Function

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269PubMed:10196521, ECO:0000269PubMed:10966924}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. {ECO:0000269PubMed:10196521, ECO:0000269PubMed:10966924, ECO:0000269PubMed:9933568}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005329	dopamine transmembrane transporter activity
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0019534	toxin transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0006855	drug transmembrane transport
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0032098	regulation of appetite
GO:0034220	ion transmembrane transport
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051608	histamine transport
GO:0051615	histamine uptake
GO:0055085	transmembrane transport
GO:1901998	toxin transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75751

PhosphoSite