Homo sapiens Gene: DRD5
Summary
InnateDB Gene IDBG-9881.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRD5
Gene Name dopamine receptor D5
Synonyms DBDR; DRD1B; DRD1L2;
Species Homo sapiens
Ensembl Gene ENSG00000169676
Encoded Proteins
dopamine receptor D5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:9781680-9784009
Strand Forward strand
Band p16.1
Transcripts
ENST00000304374 ENSP00000306129
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001588 dopamine receptor activity, coupled via Gs
GO:0004930 G-protein coupled receptor activity
GO:0004952 dopamine receptor activity
GO:0035240 dopamine binding
Biological Process
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0001992 regulation of systemic arterial blood pressure by vasopressin
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007268 synaptic transmission
GO:0007617 mating behavior
GO:0008306 associative learning
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0019226 transmission of nerve impulse
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045776 negative regulation of blood pressure
GO:0045924 regulation of female receptivity
GO:0046960 sensitization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060292 long term synaptic depression
GO:0071870 cellular response to catecholamine stimulus
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0031526 brush border membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Dopamine receptors pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
INOH
GPCR signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.380681 Hs.457002 Hs.568236
RefSeq NM_000798 XM_005276148 XM_005277459
HUGO
OMIM
CCDS CCDS3405
HPRD 00542
IMGT
EMBL
GenPept
RNA Seq Atlas