Version 5.4
Homo sapiens Gene: PACRG
Summary
InnateDB Gene IDBG-98861.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACRG
Gene Name PARK2 co-regulated
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112530
Encoded Proteins
IDBP-98863
PARK2 co-regulated
IDBP-98865
PARK2 co-regulated
IDBP-98867
PARK2 co-regulated
IDBP-591487
PARK2 co-regulated
IDBP-588056
PARK2 co-regulated
IDBP-591534
PARK2 co-regulated
IDBP-809162
PARK2 co-regulated
IDBP-809163
PARK2 co-regulated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:162727132-163315492
Strand Forward strand
Band q26
Transcripts
ENST00000366889 ENSP00000355855
ENST00000366888 ENSP00000355854
ENST00000337019 ENSP00000337946
ENST00000542669
ENST00000544266
ENST00000541974 ENSP00000440706
ENST00000534958 ENSP00000442879
ENST00000545186
ENST00000542936 ENSP00000438242
ENST00000621363 ENSP00000477605
ENST00000611387 ENSP00000481001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005929 cilium
GO:0044297 cell body
GO:0097225 sperm midpiece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037196
View Gene Order
ENSBTAG00000011106
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.25791 Hs.653689
RefSeq NM_001080378 NM_001080379 NM_152410 XM_006715343
HUGO
OMIM
CCDS CCDS43524 CCDS5284
HPRD 07465
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca