Version 5.4
Homo sapiens Protein: PACRG
Summary
InnateDB Protein IDBP-98867.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PACRG
Protein Name PARK2 co-regulated
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000337946
InnateDB Gene IDBG-98861 (PACRG)
Protein Structure
UniProt Annotation
Function Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. {ECO:0000269PubMed:14532270}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte- derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005929 cilium
GO:0044297 cell body
GO:0097225 sperm midpiece
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
IPR019399 Parkin co-regulated protein
PFAM PF10274
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96M98
PhosphoSite PhosphoSite-Q96M98
TrEMBL
UniProt Splice Variant
Entrez Gene 135138
UniGene Hs.653689
RefSeq NP_689623
HUGO HGNC:19152
OMIM 608427
CCDS CCDS5284
HPRD 07465
IMGT
EMBL AF546872 AK057286 AL031121 AL078585 AL137182 AL354942 AL590286 AL603788 AP001576 BC030642 BC044227 BK001670 CH471051
GenPept AAH30642 AAH44227 AAN37911 BAB71410 CAI16054 CAI19951 CAI21557 DAA02134 EAW47565 EAW47566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca