Homo sapiens Gene: MLLT4
Summary
InnateDB Gene IDBG-99115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLLT4
Gene Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Synonyms AF6;
Species Homo sapiens
Ensembl Gene ENSG00000130396
Encoded Proteins
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:167826922-167972023
Strand Forward strand
Band q27
Transcripts
ENST00000351017 ENSP00000252692
ENST00000344191 ENSP00000341118
ENST00000366809
ENST00000366806 ENSP00000355771
ENST00000400825 ENSP00000383626
ENST00000400824 ENSP00000383625
ENST00000400822 ENSP00000383623
ENST00000392112 ENSP00000375960
ENST00000392108 ENSP00000375956
ENST00000423229 ENSP00000414675
ENST00000447894 ENSP00000404595
ENST00000503021
ENST00000511637
ENST00000497596 ENSP00000426462
ENST00000507679
ENST00000509296
ENST00000507704 ENSP00000421441
ENST00000476946 ENSP00000424188
ENST00000485634 ENSP00000423035
ENST00000515794 ENSP00000422166
ENST00000511503
ENST00000486649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0030054 cell junction
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
INOH
PID BIOCARTA
PID NCI
E-cadherin signaling in the nascent adherens junction
Nectin adhesion pathway
SHP2 signaling
Stabilization and expansion of the E-cadherin adherens junction
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL J3KN01
UniProt Splice Variant
Entrez Gene 4301
UniGene Hs.614974 Hs.619107 Hs.741785
RefSeq XM_005266996 XM_005266997 XM_006715483 XM_006715484 XM_006715485 XM_006715486 XM_006715487 XM_006715488 XM_006715492 NM_001040000 NM_001207008 NM_001291964 XM_006715494
HUGO HGNC:7137
OMIM 159559
CCDS CCDS47517 CCDS75553
HPRD 01164
IMGT
EMBL AL009178 AL049698 AL731868
GenPept
RNA Seq Atlas 4301