Version 5.4
Homo sapiens Gene: MLLT4
Summary
InnateDB Gene IDBG-99115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLLT4
Gene Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Synonyms AF6
Species Homo sapiens
Ensembl Gene ENSG00000130396
Encoded Proteins
IDBP-99117
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-99119
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-99123
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-227321
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-227323
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-227325
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-246319
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-246321
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-388301
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-388303
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-485133
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-474626
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-475915
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-484480
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IDBP-482546
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:167826922-167972023
Strand Forward strand
Band q27
Transcripts
ENST00000351017 ENSP00000252692
ENST00000344191 ENSP00000341118
ENST00000366809
ENST00000366806 ENSP00000355771
ENST00000400825 ENSP00000383626
ENST00000400824 ENSP00000383625
ENST00000400822 ENSP00000383623
ENST00000392112 ENSP00000375960
ENST00000392108 ENSP00000375956
ENST00000423229 ENSP00000414675
ENST00000447894 ENSP00000404595
ENST00000503021
ENST00000511637
ENST00000497596 ENSP00000426462
ENST00000507679
ENST00000509296
ENST00000507704 ENSP00000421441
ENST00000476946 ENSP00000424188
ENST00000485634 ENSP00000423035
ENST00000515794 ENSP00000422166
ENST00000511503
ENST00000486649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 81 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0030054 cell junction
GO:0045177 apical part of cell
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068036
View Gene Order
ENSBTAG00000005557
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
nectin_pathway
Nectin adhesion pathway
shp2_pathway
SHP2 signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614974 Hs.619107 Hs.741785
RefSeq NM_001040000 NM_001207008 NM_001291964 XM_005266996 XM_005266997 XM_006715483 XM_006715484 XM_006715485 XM_006715486 XM_006715487 XM_006715488 XM_006715492 XM_006715494
HUGO
OMIM
CCDS CCDS47517 CCDS75553
HPRD 01164
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca