Homo sapiens Gene: PDCD2
Summary
InnateDB Gene IDBG-99325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDCD2
Gene Name programmed cell death 2
Synonyms RP8; ZMYND7;
Species Homo sapiens
Ensembl Gene ENSG00000071994
Encoded Proteins
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
programmed cell death 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:170575295-170584692
Strand Reverse strand
Band q27
Transcripts
ENST00000167218 ENSP00000167218
ENST00000392090 ENSP00000375940
ENST00000453163 ENSP00000402524
ENST00000443345 ENSP00000397272
ENST00000541970 ENSP00000439467
ENST00000543284
ENST00000545869 ENSP00000441977
ENST00000542896 ENSP00000439914
ENST00000544866 ENSP00000441098
ENST00000539212 ENSP00000439236
ENST00000538195 ENSP00000442815
ENST00000537445 ENSP00000440572
ENST00000544336 ENSP00000444066
ENST00000544755 ENSP00000440117
ENST00000614056 ENSP00000481860
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0012501 programmed cell death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.367900 Hs.741995 Hs.743857
RefSeq NM_001199461 NM_001199462 NM_001199463 NM_001199464 NM_002598 NM_144781 XM_006715498
HUGO
OMIM
CCDS CCDS47521 CCDS5316 CCDS56460 CCDS56461 CCDS56462 CCDS75557
HPRD 02922
IMGT
EMBL
GenPept
RNA Seq Atlas