Version 5.4
Homo sapiens Gene: XPO7
Summary
InnateDB Gene IDBG-9943.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPO7
Gene Name exportin 7
Synonyms EXP7; RANBP16
Species Homo sapiens
Ensembl Gene ENSG00000130227
Encoded Proteins
IDBP-9945
exportin 7
IDBP-362257
exportin 7
IDBP-476378
exportin 7
IDBP-480363
exportin 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:21919671-22006585
Strand Forward strand
Band p21.3
Transcripts
ENST00000252512 ENSP00000252512
ENST00000433566 ENSP00000410249
ENST00000521303 ENSP00000429290
ENST00000519769
ENST00000518017
ENST00000520754
ENST00000518808
ENST00000517551 ENSP00000429317
ENST00000522015
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005049 nuclear export signal receptor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022100
View Gene Order
ENSBTAG00000047628
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.172685
RefSeq NM_015024
HUGO
OMIM
CCDS CCDS47818
HPRD 05846
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca