Version 5.4
Homo sapiens Gene: TRIM69
Summary
InnateDB Gene IDBG-9954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM69
Gene Name tripartite motif containing 69
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185880
Encoded Proteins
IDBP-9956
tripartite motif containing 69
IDBP-9958
tripartite motif containing 69
IDBP-584271
tripartite motif containing 69
IDBP-586873
tripartite motif containing 69
IDBP-600415
tripartite motif containing 69
IDBP-592660
tripartite motif containing 69
IDBP-602026
tripartite motif containing 69
IDBP-598585
tripartite motif containing 69
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:44728988-44767829
Strand Forward strand
Band q21.1
Transcripts
ENST00000338264 ENSP00000342922
ENST00000329464 ENSP00000332284
ENST00000559390 ENSP00000453177
ENST00000560141
ENST00000560554
ENST00000559315
ENST00000561237
ENST00000560442 ENSP00000453549
ENST00000558329 ENSP00000453332
ENST00000561043 ENSP00000453077
ENST00000558173 ENSP00000452855
ENST00000561170 ENSP00000452739
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033368
View Gene Order
ENSBTAG00000007518
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.489254 Hs.733913
RefSeq NM_001301145 NM_001301146 NM_080745 NM_182985 XM_006720392
HUGO
OMIM
CCDS CCDS10114 CCDS32220 CCDS73719
HPRD 11518
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca