InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM69

Summary

InnateDB Protein

IDBP-584271.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM69

Protein Name

tripartite motif containing 69

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000453177

InnateDB Gene

IDBG-9954 (TRIM69)

Protein Structure

UniProt Annotation

Function

May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. {ECO:0000269PubMed:23131556}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23131556}. Nucleus {ECO:0000269PubMed:23131556}. Nucleus speckle {ECO:0000269PubMed:23131556}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00622
PF13765
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00184
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt