Version 5.4
Homo sapiens Gene: IL23R
Summary
InnateDB Gene IDBG-99558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL23R
Gene Name interleukin 23 receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162594
Encoded Proteins
IDBP-99560
interleukin 23 receptor
IDBP-239992
interleukin 23 receptor
IDBP-385622
interleukin 23 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:67166400-67259979
Strand Forward strand
Band p31.3
Transcripts
ENST00000347310 ENSP00000321345
ENST00000395227 ENSP00000378652
ENST00000425614 ENSP00000387640
ENST00000473881
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0042019 interleukin-23 binding
GO:0042020 interleukin-23 receptor activity
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0006954 inflammatory response
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0032496 response to lipopolysaccharide
GO:0032693 negative regulation of interleukin-10 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034341 response to interferon-gamma
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042520 positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043382 positive regulation of memory T cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment
Cellular Component
GO:0043235 receptor complex
GO:0072536 interleukin-23 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049093
View Gene Order
ENSBTAG00000014983
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL D9N2T9
UniProt Splice Variant
Entrez Gene 149233
UniGene Hs.677426
RefSeq XM_005270517 NM_144701
HUGO HGNC:19100
OMIM 607562
CCDS CCDS637
HPRD 16249
IMGT
EMBL AB542702
GenPept BAJ13471
RNA Seq Atlas 149233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca