Version 5.4
Homo sapiens Gene: LHX8
Summary
InnateDB Gene IDBG-99751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX8
Gene Name LIM homeobox 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162624
Encoded Proteins
IDBP-99753
LIM homeobox 8
IDBP-99755
LIM homeobox 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:75128434-75161533
Strand Forward strand
Band p31.1
Transcripts
ENST00000294638 ENSP00000294638
ENST00000356261 ENSP00000348597
ENST00000607240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007611 learning or memory
GO:0008585 female gonad development
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0042475 odontogenesis of dentin-containing tooth
Cellular Component
GO:0001674 female germ cell nucleus
GO:0005634 nucleus
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
ENSBTAG00000019192
Not yet available
ENSMUSG00000096225
View Gene Order
Cross-References
SwissProt Q68G74
TrEMBL Q6SV70 Q9BYB7
UniProt Splice Variant
Entrez Gene 431707
UniGene Hs.403934 Hs.629356
RefSeq NM_001001933 NM_001256114
HUGO HGNC:28838
OMIM 604425
CCDS CCDS30756 CCDS58008
HPRD
IMGT
EMBL AB050476 AC099786 AY449522 AY449523 BC040321
GenPept AAH40321 AAR18075 BAB40306
RNA Seq Atlas 431707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca