Version 5.4
Mus musculus Gene: Lhx8
Summary
InnateDB Gene IDBG-706462.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx8
Gene Name LIM homeobox protein 8
Synonyms L3; Lhx7
Species Mus musculus
Ensembl Gene ENSMUSG00000096225
Encoded Proteins
IDBP-622019
LIM homeobox protein 8
IDBP-622020
LIM homeobox protein 8
IDBP-717694
IDBP-716876
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162624:
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:154306294-154330561
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000169671 ENSMUSP00000126035
ENSMUST00000168508
ENSMUST00000167744 ENSMUSP00000129860
ENSMUST00000176163 ENSMUSP00000134853
ENSMUST00000177846 ENSMUSP00000136047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007611 learning or memory
GO:0008585 female gonad development
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0042475 odontogenesis of dentin-containing tooth
Cellular Component
GO:0001674 female germ cell nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162624
View Gene Order
ENSBTAG00000019192
Not yet available
Cross-References
SwissProt
TrEMBL E9Q344 H3BJ54
UniProt Splice Variant
Entrez Gene 16875
UniGene Mm.15530 Mm.422369
RefSeq XM_006501071 NM_010713 XM_006501072
OMIM
CCDS CCDS17926
HPRD
IMGT
MGI ID MGI:1096343
MGI Symbol Lhx8
EMBL AC119163
GenPept
RNA Seq Atlas 16875

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca