Mus musculus Gene: Lhx8
InnateDB Gene IDBG-706462.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx8
Gene Name LIM homeobox protein 8
Synonyms L3; Lhx7
Species Mus musculus
Ensembl Gene ENSMUSG00000096225
Encoded Proteins
LIM homeobox protein 8
LIM homeobox protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162624:
The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:154306294-154330561
Strand Reverse strand
Band H4
ENSMUST00000169671 ENSMUSP00000126035
ENSMUST00000167744 ENSMUSP00000129860
ENSMUST00000176163 ENSMUSP00000134853
ENSMUST00000177846 ENSMUSP00000136047
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007611 learning or memory
GO:0008585 female gonad development
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0042475 odontogenesis of dentin-containing tooth
Cellular Component
GO:0001674 female germ cell nucleus
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
TrEMBL E9Q344 H3BJ54
UniProt Splice Variant
Entrez Gene 16875
UniGene Mm.15530 Mm.422369
RefSeq XM_006501071 NM_010713 XM_006501072
MGI ID MGI:1096343
MGI Symbol Lhx8
EMBL AC119163
RNA Seq Atlas 16875