InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AK5

Summary

InnateDB Gene

IDBG-99803.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK5

Gene Name

adenylate kinase 5

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000154027

Encoded Proteins

IDBP-99811

adenylate kinase 5

IDBP-99815

adenylate kinase 5

IDBP-601043

adenylate kinase 5

IDBP-591772

adenylate kinase 5

IDBP-592779

adenylate kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:77282051-77559969

Strand

Forward strand

Band

p31.1

Transcripts

ENST00000354567	ENSP00000346577
ENST00000317704
ENST00000344720	ENSP00000341430
ENST00000478407	ENSP00000434409
ENST00000469394
ENST00000466114
ENST00000465146
ENST00000478255	ENSP00000433915
ENST00000466393
ENST00000524494
ENST00000530826
ENST00000527263	ENSP00000436859
ENST00000531672

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0019205	nucleobase-containing compound kinase activity
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006172	ADP biosynthetic process
GO:0006173	dADP biosynthetic process
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0009220	pyrimidine ribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process
GO:0046034	ATP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039058

View Gene Order

ENSBTAG00000017411

Not yet available

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.559718

RefSeq

NM_012093 NM_174858 XM_006710572

HUGO

OMIM

CCDS

CCDS675 CCDS676

HPRD

10472

IMGT

EMBL

GenPept

RNA Seq Atlas