Homo sapiens Gene: AK5
Summary
InnateDB Gene IDBG-99803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AK5
Gene Name adenylate kinase 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154027
Encoded Proteins
adenylate kinase 5
adenylate kinase 5
adenylate kinase 5
adenylate kinase 5
adenylate kinase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:77282051-77559969
Strand Forward strand
Band p31.1
Transcripts
ENST00000354567 ENSP00000346577
ENST00000317704
ENST00000344720 ENSP00000341430
ENST00000478407 ENSP00000434409
ENST00000469394
ENST00000466114
ENST00000465146
ENST00000478255 ENSP00000433915
ENST00000466393
ENST00000524494
ENST00000530826
ENST00000527263 ENSP00000436859
ENST00000531672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004017 adenylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005524 ATP binding
GO:0019205 nucleobase-containing compound kinase activity
GO:0019206 nucleoside kinase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006172 ADP biosynthetic process
GO:0006173 dADP biosynthetic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0016310 phosphorylation
GO:0044281 small molecule metabolic process
GO:0046034 ATP metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis and interconversion of nucleotide di- and triphosphates pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.559718
RefSeq NM_012093 NM_174858 XM_006710572
HUGO
OMIM
CCDS CCDS675 CCDS676
HPRD 10472
IMGT
EMBL
GenPept
RNA Seq Atlas