InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AK5

Summary

InnateDB Protein

IDBP-99811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK5

Protein Name

adenylate kinase 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000346577

InnateDB Gene

IDBG-99803 (AK5)

Protein Structure

UniProt Annotation

Function

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269PubMed:19647735, ECO:0000269PubMed:23416111}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19647735}.

Disease Associations

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0019205	nucleobase-containing compound kinase activity
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006172	ADP biosynthetic process
GO:0006173	dADP biosynthetic process
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0009220	pyrimidine ribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0016310	phosphorylation
GO:0044281	small molecule metabolic process
GO:0046034	ATP metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR006267 Adenylate kinase, isozyme 1/5
IPR007858 Dpy-30 motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02197
PF05186

PRINTS

PR00094

PIRSF

SMART

SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt