Version 5.4
Homo sapiens Gene: RDH11
Summary
InnateDB Gene IDBG-9982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH11
Gene Name retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072042
Encoded Proteins
IDBP-9984
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-372917
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-599038
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-584883
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-596560
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-587693
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-596045
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
IDBP-602906
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67676801-67695814
Strand Reverse strand
Band q24.1
Transcripts
ENST00000381346 ENSP00000370750
ENST00000428130 ENSP00000416395
ENST00000553384 ENSP00000452079
ENST00000553578
ENST00000554731 ENSP00000451280
ENST00000554035 ENSP00000450802
ENST00000553816
ENST00000557273 ENSP00000450651
ENST00000557726 ENSP00000450435
ENST00000557331 ENSP00000452108
ENST00000556692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
GO:0052650 NADP-retinol dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0007603 phototransduction, visible light
GO:0008152 metabolic process
GO:0016062 adaptation of rhodopsin mediated signaling
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066441
View Gene Order
ENSBTAG00000001950
Not yet available
Pathways
NETPATH
REACTOME
REACT_160156
The canonical retinoid cycle in rods (twilight vision) pathway
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.607890 Hs.623323 Hs.719925
RefSeq NM_001252650 NM_016026
HUGO
OMIM
CCDS CCDS32104 CCDS58326
HPRD 09707
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca