Homo sapiens Gene: RDH11
Summary
InnateDB Gene IDBG-9982.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH11
Gene Name retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072042
Encoded Proteins
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67676801-67695814
Strand Reverse strand
Band q24.1
Transcripts
ENST00000381346 ENSP00000370750
ENST00000428130 ENSP00000416395
ENST00000553384 ENSP00000452079
ENST00000553578
ENST00000554731 ENSP00000451280
ENST00000554035 ENSP00000450802
ENST00000553816
ENST00000557273 ENSP00000450651
ENST00000557726 ENSP00000450435
ENST00000557331 ENSP00000452108
ENST00000556692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050662 coenzyme binding
GO:0052650 NADP-retinol dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0007603 phototransduction, visible light
GO:0008152 metabolic process
GO:0016062 adaptation of rhodopsin mediated signaling
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0005622 intracellular
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Visual phototransduction pathway
Disease pathway
KEGG
Retinol metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G3V234
UniProt Splice Variant
Entrez Gene 51109
UniGene Hs.607890 Hs.623323 Hs.719925
RefSeq NM_016026 NM_001252650
HUGO HGNC:17964
OMIM 607849
CCDS CCDS32104 CCDS58326
HPRD 09707
IMGT
EMBL AL049779
GenPept
RNA Seq Atlas 51109