InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RDH11

Summary

InnateDB Protein

IDBP-9984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDH11

Protein Name

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370750

InnateDB Gene

IDBG-9982 (RDH11)

Protein Structure

UniProt Annotation

Function

Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12036956}; Single-pass type II membrane protein {ECO:0000269PubMed:12036956}.

Disease Associations

Tissue Specificity

Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004745	retinol dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0050662	coenzyme binding
GO:0052650	NADP-retinol dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0007603	phototransduction, visible light
GO:0008152	metabolic process
GO:0016062	adaptation of rhodopsin mediated signaling
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001917	photoreceptor inner segment
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF01370
PF00106
PF08659

PRINTS

PR00080
PR00081

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt