Homo sapiens Protein: BCL10
InnateDB Protein IDBP-100048.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL10
Protein Name B-cell CLL/lymphoma 10
Synonyms c-E10; CARMEN; CIPER; CLAP; mE10;
Species Homo sapiens
Ensembl Protein ENSP00000359612
InnateDB Gene IDBG-100044 (BCL10)
Protein Structure
UniProt Annotation
Function Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. {ECO:0000269PubMed:18264101}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:17287217}. Membrane raft {ECO:0000269PubMed:17287217}. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Disease Associations Note=A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.Note=Defects in BCL10 are involved in various types of cancer.Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle- shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The gene represented in this entry may be involved in disease pathogenesis.
Tissue Specificity Ubiquitous.
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 99 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019209 kinase activator activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0043130 ubiquitin binding
GO:0043422 protein kinase B binding
GO:0043621 protein self-association
GO:0051059 NF-kappaB binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0001843 neural tube closure
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0006968 cellular defense response
GO:0008219 cell death
GO:0009620 response to fungus
GO:0016064 immunoglobulin mediated immune response
GO:0031398 positive regulation of protein ubiquitination
GO:0032094 response to food
GO:0032765 positive regulation of mast cell cytokine production
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042109 lymphotoxin A biosynthetic process
GO:0042226 interleukin-6 biosynthetic process
GO:0042327 positive regulation of phosphorylation
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0070231 T cell apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0032449 CBM complex
GO:0042101 T cell receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0046696 lipopolysaccharide receptor complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
InterPro IPR001315 CARD domain
IPR011029 Death-like domain
PFAM PF00619
Post-translational Modifications
SwissProt O95999
PhosphoSite PhosphoSite-O95999
UniProt Splice Variant
Entrez Gene 8915
UniGene Hs.618972
RefSeq NP_003912
OMIM 603517
HPRD 04625
EMBL AF057700 AF082283 AF097732 AF100338 AF105066 AF127386 AF134395 AJ006288 AK291346 AL590113 BC053617 CH471097
GenPept AAC99767 AAD15800 AAD16428 AAD24918 AAD32597 AAD39147 AAF06894 AAH53617 BAF84035 CAA06955 CAH71557 EAW73208